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Brand name: PROGUT ®


Material: Catgut Chromic


Surgical catgut suture is a sterile absorbable suture composed of purified connective tissue (collagen) derived from the submucosal layer of sheep (Ovine) and goat intestine. Progut ® is a material which has been tanned by a treatment with chromium salt in the trivalent form and with oxidized pyrogallol to prolong its resistance to absorption and to colour the material dark brown. Progut ® is available in a range of gauge sizes and length. It is also available in the standard manner which is a non needled form and the other is a needled suture in which a stainless steel needle is attached to the suture. The surgical suture is packed in a sterilizing fluid which contains isopropanol, water, sodium benzoate and 0.40 -0.45% of ethylene oxide. Progut ® complies with the United States Pharmacopoeia for “Absorbable Surgical Suture”.   


Progut ® is for use in general soft tissue approximation and/or ligation, including use in ophthalmic procedures.


Sutures should be selected and implanted depending on the patient condition, surgical experience, surgical technique and wound size.


When Progut ® suture is implanted, a moderate tissue inflammation occurs which is a characteristic of a foreign body response. Loss of tensile strength and loss of suture mass follows as the proteolytic enzymatic digestive process resorbs the surgical catgut. Due to inherent variability of a natural material, figures for the strength loss and absorption following implantation are for guidelines only. Effective strength is usually lost by 21 – 25 days and absorption is essentially completed by 90 – 100 days. In humans, various factors may affect the tensile strength loss and rate of absorption. Two major factors are:
Infection: Progut ® is absorbed more rapidly in infected tissues than in non infected tissues.
Tissue sites: Progut ® is absorbed more rapidly in tissues where increased levels of proteolytic enzymes are present, as in the secretions from the stomach, cervix and vagina.


Contra indications:
These sutures, being non absorbable, should not be used where extended approximation of tissues under stress is required. Progut ® is contraindicated for use in cardiovascular and neurological tissues. Progut ® is contraindicated in patients with known sensitive or allergies to collagen or chromium since Progut ® is a collagen based which has been treated with chromic salt solutions.


Warnings/ precautions:
Users should be familiar with handling and knotting techniques involving catgut sutures before using this material for wound closure, since the risk of wound dehiscence may vary with the site of application and the type of suture used. Surgeons should consider the invivo performance of the catgut when selecting this suture. This suture may be inappropriate in elderly, malnourished patients or in patients suffering from conditions which may delay wound healing. As an absorbable suture, Progut ® acts transiently as a foreign body. As with any foreign body, prolonged contact of any suture with salt solutions, such as those found in urinary or bilary tracts may result in calculus formation. Acceptable surgical practice should be followed for the management of contaminated of infected wound. As with all absorbable suture material, the use of supplemental non absorbable sutures should be followed for the management of contaminated or infected wounds. As with the absorbable suture materials, the use of supplemental non – absorbable sutures should be considered by the surgeons in the closure of sites which may undergo expansion, stretching or distension or which may require additional support. Some patients may be hypersensitive to collagen or chromium and may develop immune reaction. Under some circumstances, notably orthopedic procedures, immobilizations of the joints by external support may be employed at the discretion of the surgeons. Consideration should be taken in the use of absorbable sutures in tissue with poor blood supply as suture extrusion and delayed absorption may occur.
In handling catgut suture care should be taken to avoid damage. Avoid crushing or crimping damage due to application of surgical instrument such as forceps or needle holders. Adequate knot security requires the standard surgical technique of flat and square ties with additional throws as indicated by surgical circumstances and the experience of the surgeon. Avoid unnecessary tension while when running down the knots, to reduce the occurrence or surface fraying and weakening of the strand. Care should be taken when opening the pack as it contains sterilizing fluid.
Care should be taken to avoid damage while handling the needles. Grasp the needle in an area one third to one half of the distance from the attachment end to the point. Grasping in the point area could impair the penetration, performance and cause fracture of the needle. Grasping the butt or the attachment of the needle may cause needle bending or breakage. Reshaping the needles may cause them to loose the strength and be less resistant to bending and breaking. Users should exercise caution when handling surgical needles to avoid inadvertent needle stick injury. Discard the used needles in sharp containers.


Adverse reaction:
Adverse reactions associated with the use of the device include allergic response in certain patients, transient local irritation at the wound site, followed by moderate transient inflammatory foreign body response. Like all foreign body catgut may enhance an existing reaction.


Progut ® sutures are sterilized by ethylene oxide. Don’t re-sterilize! Do not use if the pack is opened or damaged! Discard unused sutures!


Store in a cool and dry condition. Do not use after expiry date.


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